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AI that’s a “Game Changer” Finds Hidden Heart Attack Risk

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Scientists have praised technology as “game-changer” since it can identify those who are in danger of having a heart attack within the next ten years.

Using a mix of computer technology and X-rays, the artificial intelligence (AI) model is able to identify cardiac inflammation that is not visible on CT scans.

NHS England-funded five hospital trusts in Oxford, Milton Keynes, Leicester, Liverpool, and Wolverhampton are participating in a pilot study.

In a few months, an NHS decision about its use is anticipated.
Caristo Diagnostics, an Oxford University spin-off business that developed the technology, stated that it was already working on adapting it to prevent diabetes and strokes.

“This technology is transformative and game changing because for the first time we can detect the biological processes that are invisible to the human eye, which precede the development of narrowings and blockages [within the heart],” said Prof. Keith Channon, of the University of Oxford.

Patients with chest pain who are referred for a routine CT scan as part of the pilot program have the CaRi-Heart AI platform from Caristo Diagnostics analyze their scan.

The accuracy of an algorithm that identifies plaque and coronary inflammation is then confirmed by skilled operators.

Studies have indicated a connection between elevated inflammation and an increased risk of heart attacks and cardiovascular disease.

According to official statistics, the British Heart Foundation (BHF) estimates that 7.6 million people in the UK suffer from heart disease, and the yearly cost to the NHS in England is £7.4 billion.

According to the BHF, about 350,000 individuals are referred for a cardiac CT scan in the UK annually.

Eighty percent of patients in the 40,000-person Orfan research (Oxford Risk Factors and Non-invasive Imaging), which was reported in the Lancet, were returned to primary care without a clear prevention or treatment strategy.

Using that cohort as a focus, the researchers discovered that patients with coronary artery inflammation were 20–30 times more likely to die during the following ten years from a cardiac incident.

According to the BHF-funded study, 45% of the patients received medicine prescriptions or lifestyle modification recommendations as a result of the AI technology.

‘A wake-up call’

Ian Pickford is among the forty thousand patients that were involved in the research.

Following a period of severe chest pain, Ian Pickford, 58, of Barwell, Leicestershire, was referred for a CT scan in November 2023.
He was registered in the University Hospitals of Leicester NHS Trust Orfan study.

After testing utilizing the AI analysis revealed the double-glazing salesman was at risk of having a heart attack, he was advised to stop smoking, up his activity, and take statins.

Tests utilizing the AI analysis indicated the double-glazing salesman was at risk of a heart attack; as a result, he was advised to stop smoking, up his activity, and take statins.
Mr. Pickford declared, “It’s a huge wake-up call.”


“And when you see it on paper, you realise how serious it is. It’s something you can look at each day and think, ‘I’ve got to do something about this’.”

Based on the amount of fat around the arteries, the AI model calculates heart inflammation.

The Orfan study head, Prof. Charalambos Antoniades, claimed that the instruments up until this point were antiquated as risk calculators could only evaluate broad risk variables, including a patient’s obesity, diabetes, or smoking habit.

“Now, we know exactly which patient has the disease activity in their arteries before the disease has even developed,” he stated, referring to the type of AI technology available.

“This means we can move early to end the disease process and treat this patient to prevent the disease from developing and then prevent heart attacks from happening.”

The technology is presently being evaluated by the National Institute for Health and Care Excellence to see if it should be implemented throughout the National Health Service.

Approved for usage in Europe and Australia, it is currently undergoing assessment in the United States as well.

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Character AI Tests New Games to Boost User Engagement

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Character AI Tests New Games to Boost User Engagement

Character AI, a platform that lets users interact with AI-powered characters, is testing games on its desktop and mobile web apps to enhance user engagement.

The games are available to paid subscribers and a select group of free-plan users. For this initial rollout, Character AI has introduced two games: Speakeasy and War of Words.

To access the games, users can select any character they are chatting with and click the new controller icon. The app prompts users to start a separate chat for the game to preserve their ongoing conversations with the character.

In Speakeasy, players aim to get the chatbot to say a specific word without using five restricted words. For example, they might try to make the bot say “croissant” without mentioning “pastry,” “butter,” “bake,” “French,” or “flaky.”

In War of Words, users engage in a verbal duel with the character. An AI referee evaluates each round, with the competition spanning five rounds.

The company sees these games as a way to make the platform more entertaining. “Our goal as an AI entertainment company is to enhance the Character AI experience by making it more fun and immersive. This feature allows users to play games with their favorite characters while preserving the experience they enjoy,” a spokesperson said.

Users have already created their own text-based games, such as the Space Adventure Game. However, Character AI aims to expand its offerings by developing in-house games.

The company has recently undergone leadership changes. Co-founders Noam Shazeer and Daniel De Freitas departed for Google, while a former YouTube executive joined as Chief Product Officer. Dominic Perella, previously the company’s General Counsel, is now serving as interim CEO.

In an interview with TechCrunch in December, Perella emphasized that Character AI is focused on building a platform for entertainment rather than creating AI companions. “We want to create a wholesome entertainment platform where people can craft and share stories. To achieve this, we are continuously evolving our safety practices to the highest standards,” he explained.

The introduction of games aligns with strategies employed by platforms like YouTube, LinkedIn, and Netflix to boost user engagement. According to Sensor Tower, Character AI users already spend an average of 98 minutes per day on the app, and the addition of games could further increase this figure.

Last year, Character AI implemented new safety measures for teens, including clearer labels indicating that AI characters are not real people and a time-out notification for users who spend over 60 consecutive minutes on the app. These changes followed multiple lawsuits involving the company.

With the introduction of games, Character AI is taking another step toward cementing its position as a leading AI-driven entertainment platform.

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Hyzon is the most recent startup backed by SPAC to fail

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Hyzon Motors, a hydrogen fuel cell developer, has shut down after struggling to sustain operations since going public during the 2020-2021 SPAC boom. Despite positive press, warning signs persisted, culminating in the company’s downfall.

A Rocky Start and SEC Troubles

Hyzon, a spinoff from Singapore’s Horizon Fuel Cell Technologies, raised $550 million in 2021 through a reverse merger with Decarbonization Plus Acquisition Corp. However, its operations were focused on Europe, Australia, and China, with no U.S. or North American business initially.

In 2021, short-seller Blue Orca Capital accused Hyzon of fabricating orders in China, leading to an SEC investigation. The company paid a $25 million fine, and CEO Craig Knight was replaced in 2022 by Parker Meeks, a former McKinsey & Co. partner.

Attempts to Revive the Business

Under Meeks, Hyzon closed its European and Australian operations and focused on specific markets like refuse trucks. The company also partnered with Fontaine Modification to retrofit Freightliner Cascadia trucks with 110-kilowatt fuel cell systems while developing a larger 200-kW system.

Despite technological progress, Hyzon struggled to generate sales. By the third quarter of 2023, it had only $100,000 in revenue. With just $14 million in cash, the board decided on December 19 to pay creditors and shut down operations. Remaining employees in Michigan and Illinois are set to lose their jobs by February 2024.

Optimism Faded

Until its third-quarter earnings call, Meeks expressed hope, citing potential fleet contracts and falling hydrogen prices, which were projected to drop to $10-$12 per kilogram by 2025. However, Hyzon’s high truck costs and inability to secure large orders sealed its fate.

Broader Industry Struggles

Hyzon’s collapse is part of a broader trend among hydrogen fuel cell and SPAC-funded startups. German company Quantron AG entered insolvency in late 2023, while Nikola Corporation faces funding challenges. Other SPAC-backed ventures like Lordstown Motors and Embark Trucks also failed due to financial difficulties.

Hyliion, however, has managed to thrive by pivoting to a fuel-agnostic stationary generator business, securing contracts, and achieving a significant stock price increase in 2023.

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Japan’s efforts to create a dual-purpose defense startup environment

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To stay competitive in the global technological race, Japan must merge its defence and civilian innovation ecosystems, which involve diverse stakeholders. In September 2024, Japan’s Ministry of Defense and Ministry of Economy, Trade and Industry unveiled the concept of a “dual-use startup ecosystem.” This initiative seeks to integrate startups into research and development (R&D) to meet the technological demands of defence equipment.

Strengthening Defence Innovation

Prior to the announcement, the government identified approximately 200 startups in July 2023, outlining plans to support these companies with defence-related equipment and financial assistance to ease their entry into the market. The startups specialize in advanced fields such as drones, cyber defence, satellite communications, and electromagnetic wave technologies.

Leading this initiative is the Ministry of Defense’s Acquisition, Technology, and Logistics Agency through its newly established Defense Innovation Science and Technology Institute (October 2024). The aim is to efficiently incorporate civilian technologies into defence equipment, aligning with global trends where private-sector innovation plays a growing role in defence development. The model draws inspiration from the U.S. Defense Advanced Research Projects Agency (DARPA) and the Defense Innovation Unit, which rapidly integrate private-sector advancements into defence projects.

Historical Roots and Persistent Challenges

Japan’s push for dual-use technologies is not entirely new. Efforts began with the 2013 National Security Strategy and the 2014 Strategy on Defense Production and Technological Bases, emphasizing public-private partnerships. These policies responded to challenges like globalized supply chains, Japan’s deteriorating security environment, the shrinking defence industry, and the need for technological cooperation with allies.

However, gaps between policy and implementation have hindered progress. A major issue is the low profitability of the defence industry, which has driven many private companies out of the sector. Reform efforts must offer stronger incentives for startups to participate. While increased defence spending has benefited traditional firms, smaller companies and startups face uncertain gains.

Another obstacle is the private sector’s cautious stance on defence R&D, rooted in Japan’s post-war anti-militarist norms. Many academic and industrial players perceive military involvement as a reputational risk in the predominantly civilian-focused business landscape.

For instance, the Ministry of Defense’s 2015 research funding initiative faced strong opposition from the academic community, including the Science Council of Japan, which criticized it for potentially restricting free scientific inquiry. This resistance has limited the impact of defence-related reforms, and startups entering the sector may encounter similar challenges.

Emerging Opportunities in a Changing Context

Despite these hurdles, Japan’s new dual-use startup ecosystem reflects an evolving political and social landscape. Since the 2010s, Japan’s national security policies have shifted to address growing security threats and fiscal constraints. Public opinion has gradually become more open to pragmatic national security measures, although resistance persists in some sectors.

Startups, particularly those led by younger entrepreneurs who are less tied to traditional business norms, are poised to play a pivotal role in this policy’s success.

Economic Security as a Catalyst

Economic security policies are further driving changes in Japan’s defence innovation ecosystem. The 2022 Economic Security Promotion Act has marked the beginning of “economic securitisation,” incorporating critical and emerging technologies into national policy. Initiatives like the “Key and Advanced Technology R&D through Cross Community Collaboration Program” have expanded R&D budgets, with applications spanning both civilian and military domains under the label of “multi-use” technologies.

By framing defence-related R&D as part of economic security, the government is addressing concerns within Japan’s political culture. This approach may reduce normative barriers for companies and universities to engage in defence-related activities.

A Defining Moment for Japan’s Innovation Ecosystem

As economic securitisation gains traction, Japan faces an opportunity to establish a robust defence innovation ecosystem. However, this moment also demands tough decisions from the private sector about their involvement in defence projects. Balancing commercial interests with normative considerations will shape the future of Japan’s defence and civilian innovation integration.

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