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Johnson and Johnson’s single-dose coronavirus vaccine enters late-stage trial

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Johnson and Johnson said Wednesday it has started its stage three preliminary testing its potential Covid immunization.

J&J is the fourth drugmaker upheld by the Trump organization’s Covid-19 antibody program Operation Warp Speed to enter late-stage testing. The others are Moderna, Pfizer and AstraZeneca.

The preliminary will select up to 60,000 grown-up volunteers across 215 areas in the U.S. also, different nations, as per the National Institute of Allergy and Infectious Diseases. Members will be haphazardly chosen to get a portion of the possible antibody or a fake treatment, as per subtleties of the preliminary, which will decide if the immunization is sheltered and successful.

“Four COVID-19 vaccine candidates are in Phase 3 clinical testing in the United States just over eight months after SARS-CoV-2 was identified,” institute director Dr. Anthony Fauci said in a statement.

“This is an unprecedented feat for the scientific community made possible by decades of progress in vaccine technology and a coordinated, strategic approach across government, industry and academia,” he said. “It is likely that multiple COVID-19 vaccine regimens will be required to meet the global need. The Janssen candidate has showed promise in early-stage testing and may be especially useful in controlling the pandemic if shown to be protective after a single dose.”

J&J, whose Janssen auxiliary is situated in Belgium, has said it is utilizing similar advances it used to build up its trial Ebola antibody. It includes brushing hereditary material from the Covid with an altered adenovirus that is known to cause basic colds in people.

Preclinical examinations have indicated J&J’s potential Covid-19 antibody can create a promising reaction in nonhuman primates and hamsters.

Paul Stoffels, J&J’s boss logical official, told correspondents on a telephone call Tuesday that beginning phase preliminary information, which will be delivered “imminently,” shows the insusceptible reaction in people was “comparable to animals, which were protected.” He likewise said the antibody had all the earmarks of being all around endured, with manifestations, for example, fever settling inside 48 hours.

He said it will probably take a month and a half to two months to arrive at 60,000 members, permitting J&J to enlist a various companion. The preliminary will incorporate those both with and without comorbidities related with an expanded danger for movement to serious Covid-19, and will mean to enlist members in Argentina, Brazil, Chile, Colombia, Mexico, Peru, South Africa and the United States.

“There are a lot of what we call ‘readiness cohorts,’ where we have predetermined in high risk areas the specific populations we want to target,” he said. “The data teams have been working hard to find out where in the U.S., where in other parts of the world, we can get access to the people and parts of the population at high risk and diverse, which we need to have in the clinical trials.”

The advancement comes as President Donald Trump says the U.S. could locate a protected and successful immunization before the finish of October and have enough antibody portions to vaccinate each American by April.

Asked which drugmaker could be the first to win U.S. endorsement, Trump told “Fox News” on Monday that Pfizer, Moderna and AstraZeneca are advancing great. He included J&J’s immunization will “probably be a little later.”

The U.S. Branch of Health and Human Services reported on Aug. 5 that it arrived at an arrangement with Janssen, J&J’s drug auxiliary, worth around $1 billion for 100 million dosages of its antibody. The arrangement gives the national government the alternative to arrange an extra 200 million dosages, as per the declaration.

The stage three preliminary will be mutually financed by J&J, the National Institutes of Health and NIAID, Stoffels said Tuesday.

J&J has recently said it envisions conceivable immunization bunches for a potential crisis utilize approval accessible in mid 2021. The organization said it has proceeded with the scaling up of its assembling limit and stays on target to meet its objective of giving a billion portions of an antibody every year.

General wellbeing authorities and irresistible infection specialists state world pioneers will require a variety of medications and immunizations to crush the infection, which rose under 10 months prior.

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Character AI Tests New Games to Boost User Engagement

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Character AI Tests New Games to Boost User Engagement

Character AI, a platform that lets users interact with AI-powered characters, is testing games on its desktop and mobile web apps to enhance user engagement.

The games are available to paid subscribers and a select group of free-plan users. For this initial rollout, Character AI has introduced two games: Speakeasy and War of Words.

To access the games, users can select any character they are chatting with and click the new controller icon. The app prompts users to start a separate chat for the game to preserve their ongoing conversations with the character.

In Speakeasy, players aim to get the chatbot to say a specific word without using five restricted words. For example, they might try to make the bot say “croissant” without mentioning “pastry,” “butter,” “bake,” “French,” or “flaky.”

In War of Words, users engage in a verbal duel with the character. An AI referee evaluates each round, with the competition spanning five rounds.

The company sees these games as a way to make the platform more entertaining. “Our goal as an AI entertainment company is to enhance the Character AI experience by making it more fun and immersive. This feature allows users to play games with their favorite characters while preserving the experience they enjoy,” a spokesperson said.

Users have already created their own text-based games, such as the Space Adventure Game. However, Character AI aims to expand its offerings by developing in-house games.

The company has recently undergone leadership changes. Co-founders Noam Shazeer and Daniel De Freitas departed for Google, while a former YouTube executive joined as Chief Product Officer. Dominic Perella, previously the company’s General Counsel, is now serving as interim CEO.

In an interview with TechCrunch in December, Perella emphasized that Character AI is focused on building a platform for entertainment rather than creating AI companions. “We want to create a wholesome entertainment platform where people can craft and share stories. To achieve this, we are continuously evolving our safety practices to the highest standards,” he explained.

The introduction of games aligns with strategies employed by platforms like YouTube, LinkedIn, and Netflix to boost user engagement. According to Sensor Tower, Character AI users already spend an average of 98 minutes per day on the app, and the addition of games could further increase this figure.

Last year, Character AI implemented new safety measures for teens, including clearer labels indicating that AI characters are not real people and a time-out notification for users who spend over 60 consecutive minutes on the app. These changes followed multiple lawsuits involving the company.

With the introduction of games, Character AI is taking another step toward cementing its position as a leading AI-driven entertainment platform.

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Hyzon is the most recent startup backed by SPAC to fail

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Hyzon Motors, a hydrogen fuel cell developer, has shut down after struggling to sustain operations since going public during the 2020-2021 SPAC boom. Despite positive press, warning signs persisted, culminating in the company’s downfall.

A Rocky Start and SEC Troubles

Hyzon, a spinoff from Singapore’s Horizon Fuel Cell Technologies, raised $550 million in 2021 through a reverse merger with Decarbonization Plus Acquisition Corp. However, its operations were focused on Europe, Australia, and China, with no U.S. or North American business initially.

In 2021, short-seller Blue Orca Capital accused Hyzon of fabricating orders in China, leading to an SEC investigation. The company paid a $25 million fine, and CEO Craig Knight was replaced in 2022 by Parker Meeks, a former McKinsey & Co. partner.

Attempts to Revive the Business

Under Meeks, Hyzon closed its European and Australian operations and focused on specific markets like refuse trucks. The company also partnered with Fontaine Modification to retrofit Freightliner Cascadia trucks with 110-kilowatt fuel cell systems while developing a larger 200-kW system.

Despite technological progress, Hyzon struggled to generate sales. By the third quarter of 2023, it had only $100,000 in revenue. With just $14 million in cash, the board decided on December 19 to pay creditors and shut down operations. Remaining employees in Michigan and Illinois are set to lose their jobs by February 2024.

Optimism Faded

Until its third-quarter earnings call, Meeks expressed hope, citing potential fleet contracts and falling hydrogen prices, which were projected to drop to $10-$12 per kilogram by 2025. However, Hyzon’s high truck costs and inability to secure large orders sealed its fate.

Broader Industry Struggles

Hyzon’s collapse is part of a broader trend among hydrogen fuel cell and SPAC-funded startups. German company Quantron AG entered insolvency in late 2023, while Nikola Corporation faces funding challenges. Other SPAC-backed ventures like Lordstown Motors and Embark Trucks also failed due to financial difficulties.

Hyliion, however, has managed to thrive by pivoting to a fuel-agnostic stationary generator business, securing contracts, and achieving a significant stock price increase in 2023.

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Japan’s efforts to create a dual-purpose defense startup environment

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To stay competitive in the global technological race, Japan must merge its defence and civilian innovation ecosystems, which involve diverse stakeholders. In September 2024, Japan’s Ministry of Defense and Ministry of Economy, Trade and Industry unveiled the concept of a “dual-use startup ecosystem.” This initiative seeks to integrate startups into research and development (R&D) to meet the technological demands of defence equipment.

Strengthening Defence Innovation

Prior to the announcement, the government identified approximately 200 startups in July 2023, outlining plans to support these companies with defence-related equipment and financial assistance to ease their entry into the market. The startups specialize in advanced fields such as drones, cyber defence, satellite communications, and electromagnetic wave technologies.

Leading this initiative is the Ministry of Defense’s Acquisition, Technology, and Logistics Agency through its newly established Defense Innovation Science and Technology Institute (October 2024). The aim is to efficiently incorporate civilian technologies into defence equipment, aligning with global trends where private-sector innovation plays a growing role in defence development. The model draws inspiration from the U.S. Defense Advanced Research Projects Agency (DARPA) and the Defense Innovation Unit, which rapidly integrate private-sector advancements into defence projects.

Historical Roots and Persistent Challenges

Japan’s push for dual-use technologies is not entirely new. Efforts began with the 2013 National Security Strategy and the 2014 Strategy on Defense Production and Technological Bases, emphasizing public-private partnerships. These policies responded to challenges like globalized supply chains, Japan’s deteriorating security environment, the shrinking defence industry, and the need for technological cooperation with allies.

However, gaps between policy and implementation have hindered progress. A major issue is the low profitability of the defence industry, which has driven many private companies out of the sector. Reform efforts must offer stronger incentives for startups to participate. While increased defence spending has benefited traditional firms, smaller companies and startups face uncertain gains.

Another obstacle is the private sector’s cautious stance on defence R&D, rooted in Japan’s post-war anti-militarist norms. Many academic and industrial players perceive military involvement as a reputational risk in the predominantly civilian-focused business landscape.

For instance, the Ministry of Defense’s 2015 research funding initiative faced strong opposition from the academic community, including the Science Council of Japan, which criticized it for potentially restricting free scientific inquiry. This resistance has limited the impact of defence-related reforms, and startups entering the sector may encounter similar challenges.

Emerging Opportunities in a Changing Context

Despite these hurdles, Japan’s new dual-use startup ecosystem reflects an evolving political and social landscape. Since the 2010s, Japan’s national security policies have shifted to address growing security threats and fiscal constraints. Public opinion has gradually become more open to pragmatic national security measures, although resistance persists in some sectors.

Startups, particularly those led by younger entrepreneurs who are less tied to traditional business norms, are poised to play a pivotal role in this policy’s success.

Economic Security as a Catalyst

Economic security policies are further driving changes in Japan’s defence innovation ecosystem. The 2022 Economic Security Promotion Act has marked the beginning of “economic securitisation,” incorporating critical and emerging technologies into national policy. Initiatives like the “Key and Advanced Technology R&D through Cross Community Collaboration Program” have expanded R&D budgets, with applications spanning both civilian and military domains under the label of “multi-use” technologies.

By framing defence-related R&D as part of economic security, the government is addressing concerns within Japan’s political culture. This approach may reduce normative barriers for companies and universities to engage in defence-related activities.

A Defining Moment for Japan’s Innovation Ecosystem

As economic securitisation gains traction, Japan faces an opportunity to establish a robust defence innovation ecosystem. However, this moment also demands tough decisions from the private sector about their involvement in defence projects. Balancing commercial interests with normative considerations will shape the future of Japan’s defence and civilian innovation integration.

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